Traditional Therapies for Skin Wound Healing

Bioprinting of skin constructs for wound healing

Extensive burns and full-thickness skin wounds are difficult to repair. Autologous split-thickness skin graft (ASSG) is still used as the gold standard in the clinic. However, the shortage of donor skin tissues is a serious problem. A potential solution to this problem is to fabricate skin constructs using biomaterial scaffolds with or without cells. Bioprinting is being applied to address the ...

Peri-wound Skin Protection: A Comparison of a New Skin Barrier vs. Traditional Therapies in Wound Management

The peri-wound skin has the potential to break down as a result of constant moisture exposure. Keeping the peri-wound skin intact has become a challenge for caregivers and patients alike. Traditionally, zinc oxide ointment or petrolatum preparations have been used as a protective barrier. These products are often messy and difficult to remove.This study compared the protective function and clin...

Methodologies of Biophysical Wound Healing Therapies

Purpose: To evaluate the effects of methodological variation of biophysical therapies on wound healing outcomes, as a preliminary study to develop a composite wound healing device. Methods: A literature search was focused on the variable devices, system configurations, input parameters, and treatment durations of negative pressure wound therapy (NPWT), electrical stimulation (ES), and low-level...

Leptin Promotes Wound Healing in the Skin

INTRODUCTION Leptin, a 16 kDa anti-obesity hormone, exhibits various physiological properties. Interestingly, skin wound healing was proven to delay in leptin-deficient ob/ob mice. However, little is known on the mechanisms of this phenomenon. In this study, we attempted to elucidate a role of leptin in wound healing of skin. METHODS Immunohistochemical analysis was performed to confirm the e...

Gene Expression Profiling of Human Skin Donor Site Wound Healing to Guide Novel Regenerative Therapies